Germany aim to inflict England's first defeat since Euro 2016 and avenge last year's smash and grab when the two sides clash in Dortmund on Wednesday night.
England famously recovered from two goals down to claim a 3-2 victory courtesy of a stoppage time Eric Dier winner in Berlin 12 months ago, and the hosts are likely to have revenge on their minds.
Neither side has suffered defeat since last summer's European Championships and are well on course to secure a place in the 2018 World Cup, but this fixture will provide a timely gage of where they stand at a competitive level.
Gareth Southgate's first game in charge since being declared permanent England manager could hardly be a tougher assignment as he bids to revive optimism around the national team.
Southgate's squad contains a number of surprise inclusions, none more so than 34-year-old Jermain Defoe, who has be rewarded for his consistent goal-scoring form for Sunderland with a first international call-up since 2013.
Jamie Vardy, however, is expected to lead the attack alongside Marcus Rashford and Raheem Sterling, though Southgate is likely to use this as an opportunity to assess all options ahead of Sunday's World Cup qualifier against Lithuania.
Eric Dier of England celebrates scoring (Photo by Mike Hewitt/Getty Images)
Germany were held to a goalless draw by Italy in their last friendly outing against Italy last November and have gone 558 minutes without conceding a goal.
With the exception of Jerome Boateng, Joachim Löw has a full-strength squad at his disposal and looks set to favour Mario Gomez ahead of Thomas Muller in attack.
The likes of Mesut Ozil, Leroy Sane and Mats Hummels are also expected to start as Löw aims to extend their unbeaten run to seven games without conceding.
England threw caution to the wind after a sloppy first half display in this fixture last year but can ill-afford a similarly-slow start if they are to come out on top this time around.
Recent meetings between Germany and England have regularly produced goals, with the last six resulting in an average of 3.83 goals per game, so expect a further flurry here.
England looked vulnerable at the back in their 2-2 draw with Spain last time out and could be in for a long evening at the Westfalenstadion, with a home win looking the most appealing outcome.
Gomez has been in prolific scoring form for Wolfsburg, netting eight in his last 12 appearances, and is well-fancied to transfer that form onto the international stage by getting on the score-sheet against the Three Lions.
The match kicks off at 7.45pm GMT on Wednesday March 22 and will be shown live on ITV.
Top recommended bets:
Germany win and over 1.5 goals @ 11/10 with Paddy Power
Mario Gomez anytime goalscorer @ 11/8 with Bet365