With Grigor Dimitrov and Stanislas Wawrinka potentially awaiting him in the early rounds, it's going to be a tough start for Novak Djokovic.
Djokovic won the Madrid Masters in 2011 but the Monte Carlo champion has a very tricky draw this time round. Dimitrov has been rising to the occasion at the Masters events this year and he could be the Serb's opening opponent in round two. And Djokovic could be in for a repeat of his Aussie Open classic with Wawrinka as the in-form Swiss is seeded to play him in round three.
Meanwhile things are a little easier for defending champion Roger Federer, playing his first tournament in six weeks. Federer should be able to play himself into the tournament before a potential quarter-final clash with Richard Gasquet who's been so impressive this season.
Rafael Nadal is the bookies favourite to win his third Madrid Masters title this week and he could face Nicolas Almagro in round three in a repeat of their Barcelona final clash. The in-form Tommy Haas looks to be a potential quarter-final opponent for Nadal if Haas can get past David Ferrer. And we could see yet another Nadal-Federer clash in Madrid as the two old rivals are seeded to collide in the semi-finals.
Andy Murray will be hoping to kick start his clay-court season this week and he couldn't have asked for a better section of the draw. His quarter is filled with players struggling for form - Tomas Berdych, Janko Tipsarevic and Gilles Simon. However Murray has never played well in Madrid in the past so not everyone is expecting him to win through to the last four.