Rovers are 18th in the Championship following the weekend derby draw with Burnley, while they missed out on a place in the FA Cup semi-finals when they lost the replay with Millwall last week.
Those results appear to have been the final straw for the Rovers owners, Venky’s, who have already dismissed Steve Kean and Henning Berg this season.
A brief statement on the club’s official website confirmed: “Blackburn Rovers FC can confirm that Michael Appleton has been relieved of his duties as manager along with assistant manager Ashley Westwood, first team coach Darren Moore and head of senior recruitment Luke Dowling.”
Appleton left League One Portsmouth to take charge at Blackpool earlier this season, but he left the Seasiders after just 65 days in order to become Blackburn manager.
However, his Ewood Park reign has lasted just two days longer than his spell at Bloomfield Road, with Venky’s axing the 37-year-old after he won four of his 15 games in charge, losing six.
The Guardian newspaper are reporting that reserve team coach Gary Bowyer will take charge of first-team matters until the end of the season.