A strong performance in the Euroleague Top 16 earned Emporio Armani Milano the second seed in Group E with a 10-4 record.
On Wednesday, the Italian club will face Maccabi Tel Aviv, which placed third in Group F with an 8-6 slate.
The two teams last played each other in 2011 and split their two meetings.
Milano will welcome back Euroleague top scorer Keith Langford, who has missed his team's last few games due to injury.
Helping the American guard in the scoring chores are Curtis Jerrells, David Moss, Daniel Hackett and Alessandro Gentile.
Manning Milano's frontline are Samardo Samuels, Gani Lawal and Nicolo Melli.
For Maccabi, the players to watch for are Ricky Hickman and Devin Smith.
Also expected to contribute for the Israeli powerhouse are David Blu, Joe Ingles, Guy Pnini, Tyrese Rice and the burly Sofoklis Schortsanitis.
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