Federer’s love affair with SW19 looks set to continue as he plays Denis Istomin in round three for a place in the quarter-finals.
The world number one has not had it all his own way to date with Alejandro Falla taking a set off the great man in round one.
But he was far too good for Julien Benneteau last time out and eased into round three with a 6-2 6-2 success.
Istomin took care of Fernando Verdasco in round one before a hard-fought three-set victory over Gilles Muller in round two.
Like Federer, Williams claimed the Wimbledon title this summer and, now she is back to full fitness, she seems almost unbeatable on grass.
That is not good news for the rest of the field and she has already dealt comfortably with Jelena Jankovic and Urszula Radwanska in rounds one and two.
The American has yet to drop a set and will be looking to continue that trend in Wednesday’s encounter.
In her way is the 2010 Wimbledon finalist, who beat Sofia Arvidsson in round one before another straight-sets triumph over Francesca Schiavone.
Tour de France winner Bradley Wiggins meanwhile, will hope to cap a remarkable 2012 with victory in the Men’s Individual Time-Trial at the London Olympics on Wednesday.
The 32-year-old has made this particular sphere his forte and he will take comfort from his recent Tour Stage Nine win from Arc-et-Senans to Besancon – a route similar in distance to London’s testing 44km circuit.
However, it was in the penultimate stage from Bonneval to Chartres when the three-time Olympic gold medallist finally arrived. He stormed to victory over Team Sky and Great Britain team-mate Chris Froome by one minute and 16 seconds over the 53.5km circuit.
In football, the 2012 CONCACAF Champions League begins at 0100, with Monterrey facing Chorrillo in a Group 7 opener.
Whilst in the Copa Sudamericana, Brazilian sides Gremio RS and Coritiba meet at 0110.
There are several Champions League qualifiers on Wednesday evening also, including Fenerbahce fixture wth FC Vaslui and Slask Wroclaw clash with Helsingborg at 1945.
00:00 - TENNIS - Jimmy Wang v Filip Peliwo
00:00 - TENNIS - Renzo Olivo v Guido Pella
00:00 - TENNIS - Vania King v Jennifer Elie
01:00 - SOCCER - Monterrey v Chorrillo
01:10 - SOCCER - Emelec v Deportivo San Martin
01:10 - SOCCER - Gremio RS v Coritiba
01:30 - TENNIS - Johanna Larsson v Kai-Chen Chang
01:30 - TENNIS - Julio Cesar Campozano v Diego Sebastian Schwartzman
01:30 - TENNIS - Michelle Larcher de Brito v Sloane Stephens
03:00 - TENNIS - Emilio Gomez / Diego Hidalgo v Fabiano De Paula / Ricardo Hocevar
03:00 - SOCCER - Herediano v Real Salt Lake
03:30 - SOCCER - Deportes Tolima v CD Lara
07:25 - TABLE TENNIS - Challenger - Ochsenhausen
07:30 - TABLE TENNIS - Jiri Vrablik v Brice Ollivier
08:10 - TABLE TENNIS - Mikhail Gladyshev v Gabor Gerold
08:50 - TABLE TENNIS - Jonut Seni v Jakub Kleprlik
09:30 - TABLE TENNIS - Brice Ollivier v Adam Lindner
09:55 - TENNIS - ITF Women Trnava
10:10 - TABLE TENNIS - Jiri Vrablik v Gabor Gerold
10:50 - TABLE TENNIS - Mikhail Gladyshev v Jakub Kleprlik
11:30 - TABLE TENNIS - Jonut Seni v Zolt Sel
11:45 - BASKETBALL - Rain Or Shine v B-MEG Llamados
12:00 - SOCCER - Guangzhou Evergrande v Dalian Aerbin FC
12:45 - SOCCER - Shandong Luneng v Changchun Yatai
17:30 - SOCCER - Hapoel Kiryat Shmona v Neftchi
17:55 - TENNIS - Challenger Vancouver
18:00 - SOCCER - Sheriff Tiraspol v Dinamo Zagreb
18:45 - SOCCER - AEL v Partizan Belgrade
19:45 - SOCCER - Fenerbahce v FC Vaslui
19:45 - SOCCER - Slask Wroclaw v Helsingborg
21:00 - TENNIS - Challenger Manta
21:00 - TENNIS - WTA Washington
23:30 - SOCCER - Atletico GO v Figueirense
23:30 - SOCCER - Deportivo Quito v Leon Huanuco