Arsenal visit the San Siro on Wednesday evening to take on AC Milan in the first leg of their last 16 fixture at 1945 GMT. And Gunners fans can only hope that their suspect defence can stand up the task of shackling a potent Milanese attack, which has scored an impressive 45 goals in just 23 matches and includes Swedish legend Zlatan Ibrahimovic.
In Wednesay's other Champions League match Zenit St Petersburg will hope that they have dusted off the cobwebs in time to face Benfica at the Petrovsky Stadium. The Russian outfit haven't played a competitive match since the start of December and could be punished by the Primeira Liga leaders.
Pre-tournament favourite Ronnie O'Sullivan gets his Welsh Open campaign underway against world number 24 Marco Fu at 1300. The Rocket comes into the tournament on the back of winning the German Masters title last week and is expected to bring that form to Newport.
Star Korean paddler Joo Se Hyuk is favourite to land the Kuwait Open title this week, with the main round starting on Wednesday evening at 2200. Hyuk can continue his climb up the World Tour rankings, having recently moved up two places to sixth, should he fare well in the Arab state.
With Serie A title rivals AC Milan on Champions League duty, Juventus will look to regain top spot when they visit mid-table Parma at 1730. Juve are two points behind league leaders Milan, but have two games in hand.
Also in action in Serie on Wednesday are Atalanta and Genoa, and the former will look to put more breathing space between themselves with victory at home.
00:15 - SOCCER - Zamora v Boca Juniors
02:30 - SOCCER - Atletico Nacional Medellin v Universidad de Chile
03:30 - TENNIS - ATP San Jose
08:00 - VOLLEYBALL - KGC Women vs GS Women
08:00 - BASKETBALL - Samsung Life Bichumi Women vs KB Stars Women
09:00 - TENNIS - Challenger - Bergamo
09:00 - TENNIS - Challenger - Bergamo
09:15 - BASKETBALL - Barako Bull vs B-MEG Llamados
10:00 - BASKETBALL - Anyang KGC vs Incheon Elephants
10:00 - BASKETBALL - Goyang Orions vs Seoul SK Knights
10:00 - VOLLEYBALL - Samsung vs Dream6
11:00 - CRICKET - Pakistan v England
11:30 - BASKETBALL - Guangdong vs Bayi
11:30 - BASKETBALL - Petron Blaze Boosters vs Meralco Bolts
12:00 - VOLLEYBALL - Kuzbass v Dinamo Krasnodar
12:00 - VOLLEYBALL - UFA Ural v Yaroslavich Yaroslavl
12:55 - TABLE TENNIS - Kuwait Open
13:00 - SNOOKER - Welsh Open
13:00 - SNOOKER - Welsh Open
14:00 - TENNIS - ATP - Sao Paulo
15:00 - ICE HOCKEY - AK Bars Kazan v Dynamo Moscow
15:30 - VOLLEYBALL - EA Patron v Panathinaikos
17:30 - SOCCER - Atalanta v Genoa
17:30 - TENNIS - ATP San Jose
17:30 - SOCCER - Parma v Juventus
18:00 - VOLLEYBALL - Ethnikos Alex v Phoenix Syros
18:00 - ICE HOCKEY - HK SKP Poprad v Automobilist
18:30 - HANDBALL - Fuchse Berlin vs SC Magdeburg
19:30 - HANDBALL - Alser Puerto Sagunto vs F.C. Barcelona
19:45 - HANDBALL - Helvetia Anaitasuna vs Reale Ademar León
21:45 - SOCCER - The Strongest v Santos
